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    Haemostasis. 1991;21(5):321-7.

    Intramedullary multiple hematomas in siblings with congenital alpha-2-plasmin inhibitor deficiency: orthopedic surgery with protection by tranexamic acid.

    Takahashi Y, Tanaka T, Nakajima N, Yoshioka A, Fukui H, Miyauchi Y, Mii Y, Tamai S.

    Source

    Department of Pediatrics, Nara Medical College, Kashihara, Japan.

    Abstract

    Congenital alpha 2-plasmin inhibitor deficiency is very rare, but causes bleeding problems similar to hemophilia. Three young Japanese sisters affected with congenital alpha 2-plasmin inhibitor deficiency have been reported by us earlier. Recently we encountered a particular form of intramedullary multiple hematomas in the long bones in all of them which was not reported previously. In 2 of the sisters orthopedic operations were successfully performed by using an antiplasmin reagent: tranexamic acid. In this paper we describe the characteristics of the hematomas and the hemostatic management with tranexamic acid.

    PMID:
    1806461
    [PubMed - indexed for MEDLINE]

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