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Public Health Nutr. 2008 Oct;11(10):998-1005. Epub 2007 Dec 7.

Association of antioxidant vitamins and oxidative stress levels in pregnancy with infant growth during the first year of life.

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  • 1Department of Preventive Medicine, College of Medicine, Ewha Womans University, 911-1 Mok-dong, Yangcheon-Gu, Seoul 158-710, South Korea.



Whereas there are numerous reports in the literature relating the impact of maternal nutritional status on subsequent birth outcome, much less is known about the long-term impact on infant growth after birth. Therefore, we conducted a prospective cohort study to investigate the association of maternal micronutrient status (vitamins A, C and E, folate) and oxidative stress status in pregnancy with infant growth during the first year of life.


Prospective cohort study.


Outpatient clinic of obstetrics, Ewha Womans University Hospital, Seoul, South Korea.


Two groups were constructed for this study - the Ewha pregnancy cohort (n = 677) and the infant growth cohort comprising follow-up live newborns of all the recruited pregnant women (n = 317). Maternal serum vitamin and urinary oxidative stress levels were collected and infant weights and heights were measured at birth and at 6 and 12 months after birth.


Division of the subjects into folate-deficient and normal groups revealed that infant weight and height at 0, 6 and 12 months were adversely affected by folate deficiency. High maternal vitamin C was associated with increased infant weight and height at birth and after birth.


Our findings indicate the importance of preventing folate deficiency and supplementing vitamin C during pregnancy.

[PubMed - indexed for MEDLINE]
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