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Curr Opin Pharmacol. 2008 Feb;8(1):14-9. Epub 2007 Dec 3.

VEGF as a potential target for therapeutic intervention in depression.

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  • 1The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. jschmidt@rockefeller.edu


Antidepressants are among the most widely prescribed drugs, however the mechanism underlying their therapeutic efficacy is not known. Neurotrophic factors represent a promising class of targets for antidepressant treatments. We recently characterized a role for vascular endothelial growth factor (VEGF) in cellular and behavioral antidepressant responses. VEGF is a potent mitogen and survival factor for endothelial cells (ECs) and neurons, and modulator of synaptic transmission. Because VEGF has been implicated in a variety of diseases, understanding the molecular and cellular specificity of antidepressant-induced VEGF will be crucial to determine its potential as a therapeutic target in depression.

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