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1: Phytochemistry. 2008 Feb;69(4):1000-4. Epub 2007 Dec 3.Click here to read Links

Withanolides from Withania somnifera roots.

Misra L, Mishra P, Pandey A, Sangwan RS, Sangwan NS, Tuli R.

Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Lucknow 226015, India. laxmisra@hotmail.com

Two new and seven known withanolides along with beta-sitosterol, stigmasterol, beta-sitosterol glucoside, stigmasterol glucoside, alpha+beta glucose were isolated from the roots of Withania somnifera. Among the known compounds, Viscosa lactone B, stigmasterol, stigmasterol glucoside and alpha+beta glucose are being reported from the roots of W. somnifera for the first time. One of the new compounds contained the rare 16beta-acetoxy-17(20)-ene the other contained unusual 6alpha-hydroxy-5,7alpha-epoxy functional groups in the withasteroid skeleton. The structures were elucidated by spectroscopic methods and chemical transformations.

PMID: 18061221 [PubMed - indexed for MEDLINE]