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Nat Genet. 2008 Jan;40(1):23-5. Epub 2007 Dec 2.

Psoriasis is associated with increased beta-defensin genomic copy number.

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  • 1Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.

Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

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