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Photochemically induced RNA and DNA abasic sites.

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  • 1Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.

Abstract

Two phosphoramidite building blocks were synthesized that can easily be deprotected by UV light to reveal natural abasic sites in oligoribonucleotides as well as in oligodeoxyribonucleotides. Another building block which releases a 2'-O-methylated abasic site upon UV radiation is also described.

PMID:
18058560
[PubMed - indexed for MEDLINE]
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