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1: Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):979-83.Links

Triplex formation using oligonucleotide clamps carrying 8-aminopurines.

Aviñó A, Grimau MG, Alvira M, Eritja R, Gargallo R, Orozco M, González C.

Instituto de Biologia Molecular de Barcelona, C.S.I.C., Barcelona, Spain.

The synthesis and properties of triplex-forming DNA clamps carrying 8-aminopurines are described. The stability of triple helices is enhanced by replacing purine bases with 8-aminopurine residues. These enhanced binding properties are used for the specific capture of polypyrimidine RNA/DNA sequences of interest.

PMID: 18058521 [PubMed - indexed for MEDLINE]