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    J Biol Chem. 2008 Feb 8;283(6):3289-96. Epub 2007 Dec 5.

    Nuclear survivin has reduced stability and is not cytoprotective.

    Connell CM, Colnaghi R, Wheatley SP.

    Source

    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom.

    Abstract

    Survivin is an essential mitotic protein that is overexpressed in many cancers, and its presence is correlated with increased resistance to radiation and chemotherapy. Here we demonstrate that sending survivin into the nucleus accelerates its degradation in a cdh1-dependent manner, abolishes the radio resistance normally conferred to cells by its overexpression, and prevents survivin from inhibiting apoptosis without affecting its mitotic localization. Our data suggest that targeting survivin to the nucleus provides an efficient means of eliminating it from the cell and may prove a novel strategy in cancer treatment, particularly in combination with radiotherapy.

    PMID:
    18057009
    [PubMed - indexed for MEDLINE]
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