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Br J Psychiatry Suppl. 2007 Dec;51:s88-95. doi: 10.1192/bjp.191.51.s88.

Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis.

Author information

  • 1Department of Psychiatry and Psychotherapy, University Hospital of the University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany. stephan.ruhrmann@uk-koeln.de

Abstract

BACKGROUND:

People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances.

AIMS:

To evaluate the acute effects of a combined supportive and antipsychotic treatment on prodromal symptoms.

METHOD:

Putatively prodromal individuals were randomly assigned to a needs-focused intervention without (n=59) or with amisulpride (n=65). Outcome measures at 12-weeks effects were prodromal symptoms, global functioning and extrapyramidal side-effects.

RESULTS:

Amisulpride plus the needs-focused intervention produced superior effects on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms, and global functioning. Main side-effects were prolactin associated.

CONCLUSIONS:

Coadministration of amisulpride yielded a marked symptomatic benefit. Effects require confirmation by a placebo-controlled study.

PMID:
18055944
[PubMed - indexed for MEDLINE]
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