IFN regulation and functions in myeloid dendritic cells

Cytokine Growth Factor Rev. 2008 Feb;19(1):21-32. doi: 10.1016/j.cytogfr.2007.10.005. Epub 2007 Dec 3.

Abstract

A central issue in dendritic cells (DC) biology is to understand how type I IFNs modulate the immuno-regulatory properties of DC. In this review I will address this issue in light of the recent experimental evidence on the expression and function of these cytokines in myeloid DC. This knowledge may have important therapeutic implications in infectious and neoplastic diseases and open new perspectives in the use of IFNs as vaccine adjuvants and in the development of DC-based vaccines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / physiology
  • Dendritic Cells / immunology*
  • Humans
  • Interferon Regulatory Factors / physiology
  • Interferon Type I / genetics
  • Interferon Type I / physiology*
  • RNA Helicases / physiology
  • Receptor, Interferon alpha-beta / physiology
  • Receptors, Immunologic
  • STAT Transcription Factors / physiology
  • Signal Transduction / physiology
  • Toll-Like Receptors / physiology

Substances

  • IFNAR1 protein, human
  • Interferon Regulatory Factors
  • Interferon Type I
  • Receptors, Immunologic
  • STAT Transcription Factors
  • Toll-Like Receptors
  • Receptor, Interferon alpha-beta
  • RIGI protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases
  • RNA Helicases