Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Mitochondrion. 2008 Mar;8(2):109-16. Epub 2007 Oct 9.

The contribution of mitochondrial dysfunction to a gene-environment model of Guamanian ALS and PD.

Author information

  • 1Laboratory of Biomedical Anthropology and Neurosciences, State University of New York, PO Box 6000, Binghamton, NY 13902-6000, USA.


Scientific investigations of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) of Guam have implicated genetic and environmental risk factors in their etiology. Using brain tissue, we investigated mitochondrial dysfunction and report a higher frequency of somatic mutations in the light strand promoter (LSP) of the mitochondrial control region in Guam ALS and PD patients than in Guam controls, along with the presence of inherited mutations that may contribute to a novel gene-environment interaction risk model. Along with other risk factors, they demonstrate both the importance and significance of genetic and environmental contributions to Guam ALS and PD etiology.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk