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    Trends Biochem Sci. 2008 Jan;33(1):44-50. Epub 2007 Nov 28.

    14-3-3 cruciform-binding proteins as regulators of eukaryotic DNA replication.

    Source

    McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. maria.zannis@mcgill.ca

    Abstract

    Cruciforms are secondary DNA structures, serving as recognition signals at or near eukaryotic (yeast and mammalian) origins of DNA replication. The cruciform-binding protein is a member of the 14-3-3 protein family and binds to origins of DNA replication in a cell cycle-dependent manner. Five 14-3-3 protein isoforms (beta, gamma, epsilon, zeta and sigma) have been identified as having cruciform binding activity.

    PMID:
    18054234
    [PubMed - indexed for MEDLINE]

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