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J Nutr Biochem. 2008 May;19(5):277-86. Epub 2007 Nov 28.

Role of adipocytokines in obesity-associated insulin resistance.

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  • 1Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.

Abstract

The rapid increase of obese population in the United States has made obesity into epidemic proportion. Obesity is a strong risk factor for metabolic syndrome, type 2 diabetes mellitus, cardiovascular diseases, cancer and other diseases. Compelling evidence has demonstrated that increased adipose tissue mass is not only the consequence of obesity, but also plays a central role in the development of obesity-associated diseases. Recent studies have profoundly changed the concept of adipose tissue from being an energy depot to an active endocrine organ. The development of obesity alters adipocyte-derived hormones or cytokines expression, which provide a link between obesity and impaired insulin sensitivity and metabolic defects in other tissues. This review summarizes the current knowledge on how major adipose-derived hormones or adipocytokines influence insulin sensitivity.

PMID:
18054218
[PubMed - indexed for MEDLINE]
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