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    Bioorg Chem. 2008 Feb;36(1):29-32. Epub 2007 Dec 3.

    Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis.

    Jenkins AL, Zhang Y, Ealick SE, Begley TP.

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    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.

    Abstract

    TenA catalyzes the hydrolysis of 4-amino-5-aminomethyl-2-methylpyrimidine and participates in the salvage of base-degraded thiamin. Here, we describe mutagenesis of the active site of TenA guided by structures of the enzyme complexed to a substrate analog and to the product. Catalytic roles for each of the active site residues are identified and a mechanism for the reaction is described.

    PMID:
    18054064
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2293645
    Free PMC Article

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