Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):548-58. Epub 2007 Nov 28.

Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers.

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Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA. v.torchilin@neu.edu

Abstract

Cell-penetrating peptides (CPPs) including TAT peptide (TATp) have been successfully used for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles). Here, we will consider the main results in this area, with a special emphasis on TATp-mediated delivery of liposomes and DNA. We will also address the development of "smart" stimuli-sensitive nanocarriers, where cell-penetrating function can be activated by the decreased pH only inside the biological target minimizing thus the interaction of drug-loaded nanocarriers with non-target cells.

PMID:: 18053612; [PubMed - indexed for MEDLINE]

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