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Genome Biol. 2007;8(12):R258.

Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes.

Author information

  • 1Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, Texas 78712, USA. kris.mcgary@mail.utexas.edu

Abstract

We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.

PMID:
18053250
[PubMed - indexed for MEDLINE]
PMCID:
PMC2246260
Free PMC Article

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