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1: Genome Biol. 2007;8(12):R258.Click here to read Click here to read Links

Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes.

McGary KL, Lee I, Marcotte EM.

Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, Texas 78712, USA. kris.mcgary@mail.utexas.edu

ABSTRACT : We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.

PMID: 18053250 [PubMed - indexed for MEDLINE]

PMCID: PMC2246260