Stat Med. 1991 Dec;10(12):1959-80.

Semi-parametric and non-parametric methods for the analysis of repeated measurements with applications to clinical trials.

Source

Department of Preventive Medicine, University of Iowa, Iowa City 52242.

Abstract

Techniques applicable for the analysis of longitudinal data when the response variable is non-normal are not nearly as comprehensive as for normally-distributed outcomes. However, there have been several recent developments. Semi-parametric and non-parametric methodology for the analysis of repeated measurements is reviewed. The commonly encountered design in which, for each subject, one assesses a univariate response variable at multiple fixed time points, is considered. The types of outcomes considered include binary, ordered categorical, and continuous (but extremely non-normal) response variables. All of the methods considered allow for incomplete data due to the occurrence of missing observations. In addition, discrete and/or continuous covariates, which may be time-dependent, are accommodated by some of the approaches. The methods are demonstrated using data from three clinical trials.

PMID:: 1805321; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

MH46011/MH/NIMH NIH HHS/United States

LinkOut - more resources

Medical

Clinical Trials - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

A computer program for non-parametric analysis of incomplete repeated measures from two samples. [Comput Methods Programs Biomed...]
A computer program for non-parametric analysis of incomplete repeated measures from two samples.
Davis CS. Comput Methods Programs Biomed. 1994 Feb 1; 42(1):39-52.
Review Issues for covariance analysis of dichotomous and ordered categorical data from randomized clinical trials and non-parametric strategies for addressing them. [Stat Med. 1998]
Review Issues for covariance analysis of dichotomous and ordered categorical data from randomized clinical trials and non-parametric strategies for addressing them.
Koch GG, Tangen CM, Jung JW, Amara IA. Stat Med. 1998 Aug 15-30; 17(15-16):1863-92.
Review Longitudinal data analysis (repeated measures) in clinical trials. [Stat Med. 1999]
Review Longitudinal data analysis (repeated measures) in clinical trials.
Albert PS. Stat Med. 1999 Jul 15; 18(13):1707-32.
A computer program for regression analysis of repeated measures using generalized estimating equations. [Comput Methods Programs Biomed...]
A computer program for regression analysis of repeated measures using generalized estimating equations.
Davis CS. Comput Methods Programs Biomed. 1993 May; 40(1):15-31.
The sequential analysis of repeated binary responses: a score test for the case of three time points. [Stat Med. 2006]
The sequential analysis of repeated binary responses: a score test for the case of three time points.
Sooriyarachchi MR, Whitehead J, Whitehead A, Bolland K. Stat Med. 2006 Jul 15; 25(13):2196-214.

See reviews... See all...

Cited by 3 PubMed Central articles

Adding Subjects or Adding Measurements in Repeated Measurement Studies Under Financial Constraints. [Stat Biopharm Res. 2011]
Adding Subjects or Adding Measurements in Repeated Measurement Studies Under Financial Constraints.
Zhang S, Ahn C. Stat Biopharm Res. 2011 Feb 1; 3(1):54-64.
How many measurements for time-averaged differences in repeated measurement studies? [Contemp Clin Trials. 2011]
How many measurements for time-averaged differences in repeated measurement studies?
Zhang S, Ahn C. Contemp Clin Trials. 2011 May; 32(3):412-7. Epub 2011 Jan 15.
Initial prognostic factors in small-cell lung cancer patients predicting quality of life during chemotherapy. Swiss Group for Clinical Cancer Research (SAKK). [Br J Cancer. 1996]
Initial prognostic factors in small-cell lung cancer patients predicting quality of life during chemotherapy. Swiss Group for Clinical Cancer Research (SAKK).
Bernhard J, Hürny C, Bacchi M, Joss RA, Cavalli F, Senn HJ, Leyvraz S, Stahel R, Ludwig C, Alberto P. Br J Cancer. 1996 Nov; 74(10):1660-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Semi-parametric and non-parametric methods for the analysis of repeated measurem...
Semi-parametric and non-parametric methods for the analysis of repeated measurements with applications to clinical trials.
Stat Med. 1991 Dec ;10(12):1959-80.

PubMed
Monolith-based immobilized enzyme reactors: recent developments and applications...
Monolith-based immobilized enzyme reactors: recent developments and applications for proteome analysis.
J Sep Sci. 2007 Nov ;30(17):3050-9.

PubMed
Eating disorder symptoms in pregnancy: a prospective study.
Eating disorder symptoms in pregnancy: a prospective study.
Int J Eat Disord. 2008 Apr ;41(3):277-9.

PubMed
Evaluation of genotoxic effects in human leukocytes after in vitro exposure to 1...
Evaluation of genotoxic effects in human leukocytes after in vitro exposure to 1950 MHz UMTS radiofrequency field.
Bioelectromagnetics. 2008 Apr ;29(3):177-84.

PubMed
Genetic benefits of consanguinity through selection of genotypes protective agai...
Genetic benefits of consanguinity through selection of genotypes protective against malaria.
Hum Biol. 2007 Apr ;79(2):145-58.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: