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1: Epidemiol Perspect Innov. 2007 Dec 4;4(1):15.Click here to read Click here to read Links

Case-cohort design in practice - experiences from the MORGAM Project.

Kulathinal S, Karvanen J, Saarela O, Kuulasmaa K; the MORGAM Project.

Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. juha.karvanen@ktl.fi.

ABSTRACT: When carefully planned and analysed, the case-cohort design is a powerful choice for follow-up studies with multiple event types of interest. While the literature is rich with analysis methods for case-cohort data, little is written about the designing of a case-cohort study. Our experiences in designing, coordinating and analysing the MORGAM case-cohort study are potentially useful for other studies with similar characteristics. The motivation for using the case-cohort design in the MORGAM genetic study is discussed and issues relevant to its planning and analysis are studied. We propose solutions for appending the earlier case-cohort selection after an extension of the follow-up period and for achieving maximum overlap between earlier designs and the case-cohort design. Approaches for statistical analysis are studied in a simulation example based on the MORGAM data.

PMID: 18053196 [PubMed - as supplied by publisher]

PMCID: PMC2216006