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J Clin Psychiatry. 2007 Nov;68(11):1701-6.

Antidepressant medication treatment failure does not predict lower remission with ECT for major depressive disorder: a report from the consortium for research in electroconvulsive therapy.

Author information

  • 1Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. rasmussen.keith@mayo.edu

Abstract

OBJECTIVE:

To test whether antidepressant medication treatment failure predicts differential remission with electroconvulsive therapy (ECT) in nonpsychotic unipolar depression.

METHOD:

Depressed patients diagnosed with the Structured Clinical Interview for DSM-IV receiving ECT were assessed for medication use with the Antidepressant Treatment History Form (ATHF) (N = 345). Response to ECT was assessed with the 24-item Hamilton Rating Scale for Depression. Baseline medication treatment failure was analyzed as a possible predictor of remission status. Dates of study enrollment were from May 1997 to July 2004.

RESULTS:

Resistance to antidepressant medication as assessed by the ATHF, either taken as a whole or for any individual class of medication, was not predictive of acute remission status with ECT.

CONCLUSION:

Treatment failure with anti-depressant medication does not predict acute remission status with ECT for nonpsychotically depressed patients.

PMID:
18052563
[PubMed - indexed for MEDLINE]
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