Tidsskr Nor Laegeforen. 2007 Nov 29;127(23):3094-6.

[Adjuvant chemotherapy for colon cancer].

[Article in Norwegian]

Source

Seksjon for onkologi, Institutt for indremedisin, Universitetet i Bergen, 5021 Bergen. olav.dahl@helse-bergen.no.

Abstract

BACKGROUND:

Radical resection is the main treatment for adenocarcinoma of the colon. Adjuvant chemotherapy may reduce the recurrence rate of the disease. It is therefore important that those who may benefit from such therapy are offered the optimal regimens in due time. The background for adjuvant chemotherapy of colon cancer is presented.

MATERIAL AND METHODS:

The manuscript is based on a survey of randomized clinical trials (from 1990 to 2007) retrieved from PubMed, and on own clinical experience.

RESULTS AND INTERPRETATION:

Cure rates after curative resections of colon cancer (stage III) are improved by about 12% if patients are treated with adjuvant chemotherapy with oxaliplatin combined with 5-fluoruracil and folinat (or capecitabine) for 6 months. Certain subgroups of stage II (Dukes' stage B) are also likely to benefit from adjuvant chemotherapy.

PMID:: 18049502; [PubMed - indexed for MEDLINE]

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