Pharmacol Rep. 2007 Sep-Oct;59(5):565-72.

Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells.

Pilarski R, Poczekaj-Kostrzewska M, Ciesiołka D, Szyfter K, Gulewicz K.

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Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, PL 61-704 Poznań, Poland.

Abstract

The woody Amazonian vine Uncaria tomentosa (cat's claw) has been recently more and more popular all over the world as an immunomodulatory, antiinflammatory and anti-cancer remedy. This study investigates anti-proliferative potency of several cat's claw preparations with different quantitative and qualitative alkaloid contents on HL-60 acute promyelocytic human cells by applying trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay (MTT). By standardization and statistical comparison of the obtained results pteropodine and isomitraphylline are indicated to be most suitable for standardization of medical cat's claw preparations.

PMID:: 18048957; [PubMed - indexed for MEDLINE]

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