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Am J Respir Crit Care Med. 2008 Apr 1;177(7):743-51. Epub 2007 Nov 29.

Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study.

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  • 1Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, D-22927 Grosshansdorf, Germany. magnussen@pulmoresearch.de

Abstract

RATIONALE:

Physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD). COPD has a systemic component that includes significant extrapulmonary effects that may contribute to its severity in individual patients.

OBJECTIVES:

To investigate the association of extrapulmonary effects of the disease and its comorbidities with reduced physical activity in patients with COPD.

METHODS:

In a cross-sectional study, 170 outpatients with COPD (GOLD [Global Initiative for Chronic Obstructive Lung Disease] stages I-IV; BODE [body mass index, airway obstruction, dyspnea, and exercise capacity] score 0-10) underwent a series of tests. Physical activity was assessed over 5 to 6 consecutive days by using a multisensor accelerometer armband that records steps per day and the physical activity level (total daily energy expenditure divided by whole-night sleeping energy expenditure). Cardiovascular status was assessed by echocardiography, vascular Doppler sonography, and levels of N-terminal pro-B-type natriuretic peptide. Mental status, metabolic/muscular status, systemic inflammation, and anemia were assessed by Beck Depression Inventory, bioelectrical impedance analysis, handgrip strength, high-sensitivity C-reactive protein/fibrinogen, and hemoglobin, respectively.

MEASUREMENTS AND MAIN RESULTS:

In a multivariate linear regression analysis using either steps per day or physical activity level as a dependent variable, the extrapulmonary parameters that were associated with reduced physical activity in patients with COPD independently of GOLD stages or BODE score were N-terminal pro-B-type natriuretic peptide levels, echocardiographically measured left ventricular diastolic function, and systemic inflammation.

CONCLUSIONS:

Higher values of systemic inflammation and left cardiac dysfunction are associated with reduced physical activity in patients with COPD.

Comment in

PMID:
18048807
[PubMed - indexed for MEDLINE]
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