Cell. 2007 Nov 30;131(5):838-40.

tRNA traffic meets a cell-cycle checkpoint.

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Department of Molecular and Cellular Biology, University of Arizona, Life Sciences South 546, P.O. Box 210106, Tucson, AZ 85721-0106, USA. tweinert@email.arizona.edu

Abstract

The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression remain largely unresolved. Findings by Ghavidel et al. (2007) reported in this issue suggest that tRNA trafficking and the transcription factor Gcn4 are key intermediates in the process by which yeast cells detect DNA damage and delay cell-cycle progression at the G1 to S phase transition.

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Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint. [Cell. 2007]
Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint.Ghavidel A, Kislinger T, Pogoutse O, Sopko R, Jurisica I, Emili A. Cell. 2007 Nov 30; 131(5):915-26.

PMID:: 18045528; [PubMed - indexed for MEDLINE]

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Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint. [Cell. 2007]
Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint.
Ghavidel A, Kislinger T, Pogoutse O, Sopko R, Jurisica I, Emili A. Cell. 2007 Nov 30; 131(5):915-26.
Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability. [Genetics. 2002]
Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability.
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Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. [Cell Cycle. 2007]
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Menacho-Marquez M, Perez-Valle J, Ariño J, Gadea J, Murguía JR. Cell Cycle. 2007 Sep 15; 6(18):2302-5. Epub 2007 Jul 2.
Review Ensuring the stability of the genome: DNA damage checkpoints. [ScientificWorldJournal. 2001]
Review Ensuring the stability of the genome: DNA damage checkpoints.
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Review DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. [Mutat Res. 2000]
Review DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae.
Foiani M, Pellicioli A, Lopes M, Lucca C, Ferrari M, Liberi G, Muzi Falconi M, Plevani1 P. Mutat Res. 2000 Jun 30; 451(1-2):187-96.

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Cited by 2 PubMed Central articles

Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p. [Mol Biol Cell. 2012]
Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.
Cherkasova V, Maury LL, Bacikova D, Pridham K, Bähler J, Maraia RJ. Mol Biol Cell. 2012 Feb; 23(3):480-91. Epub 2011 Dec 7.
Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants. [Nucleic Acids Res. 2011]
Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants.
Iben JR, Epstein JA, Bayfield MA, Bruinsma MW, Hasson S, Bacikova D, Ahmad D, Rockwell D, Kittler EL, Zapp ML, et al. Nucleic Acids Res. 2011 Jun; 39(11):4728-42. Epub 2011 Feb 11.

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