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Genome Biol. 2007;8(11):R253.

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.

Author information

  • 1Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark. rber@steno.dk

Abstract

We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

PMID:
18045462
[PubMed - indexed for MEDLINE]
PMCID:
PMC2258178
Free PMC Article

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