Anesth Analg. 2007 Dec;105(6):1805-15.

Pregabalin: its pharmacology and use in pain management.

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Texas Anodyne Research Institute and Sherman Pain Care, Texas, USA. noorgajraj@aol.com

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Anesth Analg.2008 May;106(5):1584.

Abstract

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid. It is an alpha2-delta (alpha2-delta) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the alpha2-delta subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.

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Pregabalin for pain management. [Pain Pract. 2005]
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