Molecular aspects of HTLV-I infection and adult T-cell leukaemia/lymphoma

G Taylor

doi:10.1136/jcp.2007.052662

Molecular aspects of HTLV-I infection and adult T-cell leukaemia/lymphoma

J Clin Pathol. 2007 Dec;60(12):1392-6. doi: 10.1136/jcp.2007.052662.

Author

G Taylor¹

Affiliation

¹ Infectious Diseases Section, Division of Medicine Faculty, St Mary's Campus, Imperial College London, London, UK. g.p.taylor@imperial.ac.uk

Abstract

Human T-cell lymphotropic virus-I (HTLV-I) is the cause of adult T-cell leukaemia/lymphoma. Various viral proteins, especially, but not exclusively, Tax have been implicated in oncogenesis, mostly through in vitro studies. Tax transactivates a large and apparently ever expanding list of human genes through transcriptional factors. Elucidating not only the pathways but also the timing of action of HTLV proteins is important for understanding the pathogenesis and development of new treatments.

Publication types

Review

MeSH terms

Adult
Apoptosis
Cell Cycle / genetics
Cell Transformation, Neoplastic
Cell Transformation, Viral
Gene Products, tax / physiology
Genomic Instability
HTLV-I Infections / complications*
Humans
Leukemia-Lymphoma, Adult T-Cell / genetics
Leukemia-Lymphoma, Adult T-Cell / pathology
Leukemia-Lymphoma, Adult T-Cell / virology*
Transcription Factors / physiology
Viral Regulatory and Accessory Proteins / physiology

Substances

Gene Products, tax
Transcription Factors
Viral Regulatory and Accessory Proteins
tax protein, Human T-lymphotrophic virus 1