Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mech Dev. 2008 Jan-Feb;125(1-2):106-16. Epub 2007 Oct 10.

Activin signaling limits the competence for retinal regeneration from the pigmented epithelium.

Author information

  • 1Department of Biological Structure, 357420 Health Science Center, University of Washington, School of Medicine, Seattle, WA 98195, USA.

Abstract

Regeneration of the retina in amphibians is initiated by the transdifferentiation of the retinal pigmented epithelium (RPE) into neural progenitors. A similar process occurs in the early embryonic chick, but the RPE soon loses this ability. The factors that limit the competence of RPE cells to regenerate neural retina are not understood; however, factors normally involved in the development of the eye (i.e. FGF and Pax6) have also been implicated in transdifferentiation. Therefore, we tested whether activin, a TGFbeta family signaling protein shown to be important in RPE development, contributes to the loss in competence of the RPE to regenerate retina. We have found that addition of activin blocks regeneration from the RPE, even during stages when the cells are competent. Conversely, a small molecule inhibitor of the activin/TGFbeta/nodal receptors can delay, and even reverse, the developmental restriction in FGF-stimulated neural retinal regeneration.

PMID:
18042353
[PubMed - indexed for MEDLINE]
PMCID:
PMC2254174
Free PMC Article

Images from this publication.See all images (7)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk