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J Cell Biol. 2007 Dec 3;179(5):813-5. Epub 2007 Nov 26.

Plasmid segregation: spatial awareness at the molecular level.

Author information

  • 1Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark. jakobm@bmb.sdu.dk

Abstract

In bacteria, low-copy number plasmids ensure their stable inheritance by partition loci (par), which actively distribute plasmid replicates to each side of the cell division plane. Using time-lapse fluorescence microscopic tracking of segregating plasmid molecules, a new study provides novel insight into the workings of the par system from Escherichia coli plasmid R1. Despite its relative simplicity, the plasmid partition spindle shares characteristics with the mitotic machinery of eukaryotic cells.

PMID:
18039938
[PubMed - indexed for MEDLINE]
PMCID:
PMC2099191
Free PMC Article
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