Abstract
We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Gene Expression Regulation, Bacterial*
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Gene Transfer, Horizontal*
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Mice
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Mice, Inbred BALB C
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Proteome*
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Reverse Transcriptase Polymerase Chain Reaction
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Salmonella Infections, Animal / microbiology
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Salmonella typhimurium / genetics
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Salmonella typhimurium / metabolism
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Salmonella typhimurium / pathogenicity*
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Transcription, Genetic
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Virulence
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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H-NS protein, bacteria
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Proteome