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1: J Med Chem. 2007 Dec 27;50(26):6462-4. Epub 2007 Nov 27.Click here to read Click here to read Links

Novel, orally effective cyanide antidotes.

Nagasawa HT, Goon DJ, Crankshaw DL, Vince R, Patterson SE.

Center for Drug Design, University of Minnesota, Minneapolis 55455, USA. nagas001@umn.edu

A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

PMID: 18038966 [PubMed - indexed for MEDLINE]

PMCID: PMC2274902