Nat Neurosci. 2008 Jan;11(1):16-8. Epub 2007 Nov 25.

Recognition memory: opposite effects of hippocampal damage on recollection and familiarity.

Sauvage MM, Fortin NJ, Owens CB, Yonelinas AP, Eichenbaum H.

Source

Center for Memory and Brain, Boston University, Boston, MA 02215, USA.

Abstract

A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.

PMID:: 18037884; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Amygdala lesions selectively impair familiarity in recognition memory. [Nat Neurosci. 2011]
Amygdala lesions selectively impair familiarity in recognition memory.
Farovik A, Place RJ, Miller DR, Eichenbaum H. Nat Neurosci. 2011 Sep 25; 14(11):1416-7. Epub 2011 Sep 25.
Review ROC in animals: uncovering the neural substrates of recollection and familiarity in episodic recognition memory. [Conscious Cogn. 2010]
Review ROC in animals: uncovering the neural substrates of recollection and familiarity in episodic recognition memory.
Sauvage MM. Conscious Cogn. 2010 Sep; 19(3):816-28. Epub 2010 Aug 5.
Cognitive aging: a common decline of episodic recollection and spatial memory in rats. [J Neurosci. 2008]
Cognitive aging: a common decline of episodic recollection and spatial memory in rats.
Robitsek RJ, Fortin NJ, Koh MT, Gallagher M, Eichenbaum H. J Neurosci. 2008 Sep 3; 28(36):8945-54.
An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory. [Neuropsychologia. 2010]
An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory.
Eichenbaum H, Fortin N, Sauvage M, Robitsek RJ, Farovik A. Neuropsychologia. 2010 Jul; 48(8):2281-9. Epub 2009 Sep 20.
Review The role of the human hippocampus in familiarity-based and recollection-based recognition memory. [Behav Brain Res. 2010]
Review The role of the human hippocampus in familiarity-based and recollection-based recognition memory.
Wixted JT, Squire LR. Behav Brain Res. 2010 Dec 31; 215(2):197-208. Epub 2010 Apr 20.

See reviews... See all...

Cited by 14 PubMed Central articles

Review Mindspan: lessons from rat models of neurocognitive aging. [ILAR J. 2011]
Review Mindspan: lessons from rat models of neurocognitive aging.
Gallagher M, Stocker AM, Koh MT. ILAR J. 2011 Feb 8; 52(1):32-40.
The formation and stability of recognition memory: what happens upon recall? [Front Behav Neurosci. 2010]
The formation and stability of recognition memory: what happens upon recall?
Davis S, Renaudineau S, Poirier R, Poucet B, Save E, Laroche S. Front Behav Neurosci. 2010 Nov 19; 4:177. Epub 2010 Nov 19.
Review Measuring recollection and familiarity in the medial temporal lobe. [Hippocampus. 2010]
Review Measuring recollection and familiarity in the medial temporal lobe.
Wixted JT, Mickes L, Squire LR. Hippocampus. 2010 Nov; 20(11):1195-205.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Recognition memory: opposite effects of hippocampal damage on recollection and f...
Recognition memory: opposite effects of hippocampal damage on recollection and familiarity.
Nat Neurosci. 2008 Jan ;11(1):16-8. Epub 2007 Nov 25 .

PubMed
DNA primases.
DNA primases.
Annu Rev Biochem. 2001 ;70:39-80.

PubMed
Spinal manipulation for low-back pain: a treatment package agreed to by the UK c...
Spinal manipulation for low-back pain: a treatment package agreed to by the UK chiropractic, osteopathy and physiotherapy professional associations.
Man Ther. 2003 Feb ;8(1):46-51.

PubMed
A retrospective examination of in-home educational visits to reduce childhood le...
A retrospective examination of in-home educational visits to reduce childhood lead levels.
Environ Res. 1999 May ;80(4):364-8.

PubMed
Impact of blood pressure lowering on cardiovascular outcomes in normal weight, o...
Impact of blood pressure lowering on cardiovascular outcomes in normal weight, overweight, and obese individuals: the Perindopril Protection Against Recurrent Stroke Study trial.
Hypertension. 2010 May ;55(5):1193-8. Epub 2010 Mar 8 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Recognition memory: opposite effects of hippocampal damage on recollection and familiarity.

Source

Abstract

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 14 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information