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FEBS Lett. 2007 Dec 11;581(29):5727-31. Epub 2007 Nov 26.

Compound C inhibits hypoxic activation of HIF-1 independent of AMPK.

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  • 1Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. bemerlin@bidmc.harvard.edu

Abstract

The key transcription factor that regulates the cellular responses to hypoxia is hypoxia inducible factor-1 (HIF-1). The signaling mechanisms that regulate the hypoxic activation of HIF-1 are not fully understood. Our objective here was to test whether AMP-activated kinase (AMPK) was an upstream regulator of HIF-1. Our results show that AMPK is not required for the hypoxic activation of HIF-1. Interestingly, the AMPK inhibitor, Compound C, inhibits the hypoxic activation of HIF-1 independent of AMPK. Furthermore, we demonstrate that Compound C functions as a repressor of HIF-1 by inhibiting respiration and suppressing mitochondrial generated ROS.

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