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Genome Biol. 2007;8(11):228.

Chromatin, gene silencing and HIV latency.

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  • 1Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

Abstract

One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral latency to gene-silencing mechanisms.

PMID:
18036274
[PubMed - indexed for MEDLINE]
PMCID:
PMC2258194
Free PMC Article

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