Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Med Case Rep. 2007 Nov 24;1:147.

Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report.

Author information

  • 1Department of Pathology, Maulana Azad Medical College, New Delhi, India. deepalijain76@gmail.com.

Abstract

BACKGROUND:

Acute promyelocytic leukemia (APL) accounts for less than 10% of pediatric AML. Cases of APL in Down syndrome (DS) have been described in the literature rarely and it is rarer still to find the microgranular variant (M3v) of APL in trisomy 21 patients.

CASE PRESENTATION:

We present a case of a five-year-old female with Down syndrome diagnosed with acute promyelocytic leukemia (APL). She came to our hospital with bleeding manifestations. Blood and bone marrow examination revealed promyelocytes showing a few fine granules and occasional Auer rods. Based on this morphology and cytochemistry, a diagnosis of APL microgranular variant (M3v) was made.

CONCLUSION:

This case report emphasizes the importance of a high index of suspicion in the diagnosis of acute promyelocytic leukemia microgranular variant in Down syndrome.

PMID:
18036234
[PubMed]
PMCID:
PMC2211491
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk