J Enzyme Inhib Med Chem. 2007 Oct;22(5):563-9.

Synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity.

Chevreuil F, Landreau A, Séraphin D, Larcher G, Mallet S, Bouchara JP, Richomme P.

Source

Laboratoire SONAS, UPRES-EA 921, UFR des Sciences Pharmaceutiques, Angers, France.

Abstract

New 2-(2,4-dihalogenophenyl)-1-(1H-imidazol-1-yl)-3-(isoxazol-5-yl)propan-2-ols and 2-(2,4-dihalogenophenyl)-1-(1H-imidazol-1-yl)-3-(4,5-dihydroisoxazol-5-yl)propan-2-ols were synthesized by 1,3-dipolar cycloaddition between homopropargylic or homoallylic alcohols and in-situ generated nitrile oxide. Their antifungal activity was evaluated against Candida albicans, C. glabrata, Aspergillus fumigatus and an azole-resistant petite mutant of C. glabrata. Preliminary SAR results are discussed.

PMID:: 18035824; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Synthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity. [J Enzyme Inhib Med Chem. 2008]
Synthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity.
Chevreuil F, Landreau A, Seraphin D, Larcher G, Bouchara JP, Richomme P. J Enzyme Inhib Med Chem. 2008 Oct; 23(5):617-22.
Synthesis and antifungal activity of new thienyl and aryl conazoles. [J Enzyme Inhib Med Chem. 2006]
Synthesis and antifungal activity of new thienyl and aryl conazoles.
Chevreuil F, Landreau A, Seraphin D, Larcher G, Bouchara JP, Richomme P. J Enzyme Inhib Med Chem. 2006 Jun; 21(3):293-303.
Synthesis of reduced xanthatin derivatives and in vitro evaluation of their antifungal activity. [J Enzyme Inhib Med Chem. 2005]
Synthesis of reduced xanthatin derivatives and in vitro evaluation of their antifungal activity.
Pinel B, Landreau A, Seraphin D, Larcher G, Bouchara JP, Richomme P. J Enzyme Inhib Med Chem. 2005 Dec; 20(6):575-9.
Review Problems of antifungal in vitro testing in Aspergillus fumigatus. [Contrib Microbiol. 1999]
Review Problems of antifungal in vitro testing in Aspergillus fumigatus.
Espinel-Ingroff A. Contrib Microbiol. 1999; 2:139-48.
Review Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. [Eukaryot Cell. 2008]
Review Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.
Cowen LE, Steinbach WJ. Eukaryot Cell. 2008 May; 7(5):747-64. Epub 2008 Mar 28.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of the...
Synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity.
J Enzyme Inhib Med Chem. 2007 Oct ;22(5):563-9.

PubMed
The mechanism of isoniazid killing: clarity through the scope of genetics.
The mechanism of isoniazid killing: clarity through the scope of genetics.
Annu Rev Microbiol. 2007 ;61:35-50.

PubMed
[The male genital tract: A host for HIV].
[The male genital tract: A host for HIV].
Gynecol Obstet Fertil. 2007 Dec ;35(12):1245-50. Epub 2007 Nov 26 .

PubMed
Invasive lobular carcinoma of the breast: response to hormonal therapy and outco...
Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes.
Eur J Cancer. 2008 Jan ;44(1):73-83. Epub 2007 Nov 26 .

PubMed
Neuroprotection by pravastatin in acute ischemic stroke in rats.
Neuroprotection by pravastatin in acute ischemic stroke in rats.
Brain Res Rev. 2008 Jun ;58(1):48-56. Epub 2007 Nov 1 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: