Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Annu Rev Microbiol. 2007;61:215-36.

SigB-dependent general stress response in Bacillus subtilis and related gram-positive bacteria.

Author information

  • 1Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität, Greifswald 17489, Germany. hecker@uni-greifswald.de

Abstract

One of the strongest and most noticeable responses of Bacillus subtilis cells to a range of stress and starvation stimuli is the dramatic induction of about 150 SigB-dependent general stress genes. The activity of SigB itself is tightly regulated by a complex signal transduction cascade with at least three main signaling pathways that respond to environmental stress, energy depletion, or low temperature. The SigB-dependent response is conserved in related gram-positive bacteria but is missing in strictly anaerobic or in some facultatively anaerobic gram-positive bacteria. It covers functions from nonspecific and multiple stress resistance to the control of virulence in pathogenic bacteria. A comprehensive understanding of this crucial stress response is essential not only for bacterial physiology but also for applied microbiology, including pathogenicity and pathogen control.

PMID:
18035607
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk