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ACS Chem Biol. 2007 Nov 20;2(11):708-10.

Bactericidal antibiotics and oxidative stress: a radical proposal.

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  • 1Department of Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45221, USA. daniel.hassett@uc.edu, jimlay@uiuc.edu

Abstract

A recent publication suggests that many antibiotics exert their bactericidal effects via the production of hydroxyl radicals, regardless of their molecular targets. This proposal represents an abrupt departure from conventional models, and it will attract further experimental tests.

PMID:
18030985
[PubMed - indexed for MEDLINE]
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