Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside

Masahiro Ikejiri; Takayuki Ohshima; Keizo Kato; Masaaki Toyama; Takayuki Murata; Kunitada Shimotohno; Tokumi Maruyama

doi:10.1093/nass/nrm220

Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside

Nucleic Acids Symp Ser (Oxf). 2007:(51):439-40. doi: 10.1093/nass/nrm220.

Authors

Masahiro Ikejiri¹, Takayuki Ohshima, Keizo Kato, Masaaki Toyama, Takayuki Murata, Kunitada Shimotohno, Tokumi Maruyama

Affiliation

¹ Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan. ikejirim@kph.bunri-u.ac.jp

PMID: 18029775
DOI: 10.1093/nass/nrm220

Abstract

A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Deoxyribonucleosides / chemistry
Deoxyribonucleosides / pharmacology
Genome, Viral
Hepacivirus / drug effects*
Hepacivirus / genetics
Hepacivirus / physiology
Purine Nucleosides / chemical synthesis
Purine Nucleosides / chemistry*
Purine Nucleosides / pharmacology*
Purines / chemistry
Virus Replication / drug effects

Substances

Antiviral Agents
Deoxyribonucleosides
Purine Nucleosides
Purines
6-chloropurine