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Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA.

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  • 1On-site Sensing and Diagnosis Research Laboratory, Advanced Industrial Sicence and Technology, 807-1, Shukumachi, Tosu 841-0052, Japan.


In this study, we describe a development of chemically modified dsRNAs with improved biological properties. These dsRNAs possess an enhanced RNAi activity and a dramatically increased stability in cell cultured medium (containing 10% serum) in comparison with widely used 21nt siRNA. The chemically modified dsRNAs manifested a high longterm gene suppression after one week post-transfection, whereas 21nt siRNA showed a high RNAi activity only after 48 h cell transfection.

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