Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
J Am Acad Dermatol. 2008 Jan;58(1):142-8. Epub 2007 Oct 29.

Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases.

Author information

  • 1Department of Dermatology, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA.

Abstract

BACKGROUND:

Complete surgical excision for lentigo maligna (LM) and LM melanoma (LMM) in the head and neck region may be challenging because of potential significant subclinical extension.

OBJECTIVE:

We sought to review clinical and histologic features of LM and LMM and determine surgical margin necessary for complete excision.

METHODS:

We conducted a retrospective study of 117 LM and LMM cases treated with a staged margin-controlled excision technique with rush paraffin-embedded sections.

RESULTS:

The mean total surgical margin required for excision of LM was 7.1 mm and was 10.3 mm for LMM. Of the tumors diagnosed as LM on initial biopsy specimen, 16% were found to have unsuspected invasion. Total surgical margin was associated with initial clinical lesion diameter.

LIMITATIONS:

Retrospective and single-institution experience are limitations.

CONCLUSION:

This study corroborates that the standard excision margins for LM and LMM are often inadequate and occult invasive melanoma occurs in LM. An excision technique with permanent sections using a team of dermatopathology and surgery that carefully examines the central tumor and the surgical margins is reliable for the treatment of LM and LMM.

PMID:
18029055
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk