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J Allergy Clin Immunol. 2008 Jan;121(1):72-80.e3. Epub 2007 Oct 29.

Lung function, respiratory symptoms, and the menopausal transition.

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  • 1Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. francisco.real@med.uib.no

Abstract

BACKGROUND:

There is limited information on potential changes in respiratory health when women enter the menopausal transition.

OBJECTIVE:

We sought to investigate whether the menopausal transition is related to lung function and asthma and whether body mass index (BMI) modifies associations.

METHODS:

Four thousand two hundred fifty-nine women from 21 centers (ECRHS II, 2002) responded to a questionnaire concerning women's health. Women aged 45 to 56 years not using exogenous sex hormones (n = 1274) were included in the present analysis. Lung function measurements (n = 1120) and serum markers of hormonal status (follicle-stimulating hormone, luteinizing hormone, and estradiol; n = 710) were available. Logistic and linear regression analyses were adjusted for BMI, age, years of education, smoking status, center, and height.

RESULTS:

Women not menstruating for the last 6 months (n = 432, 34%) had significantly lower FEV(1) values (-120 mL [95% CI, -177 to -63]), lower forced vital capacity values (-115 mL [95% CI, -181 to -50]), and more respiratory symptoms (odds ratio [OR], 1.82 [95% CI, 1.27-2.61]) than those menstruating regularly. Results were similar when restricting analyses to those who never smoked. Associations were significantly stronger in women with BMIs of less than 23 kg/m(2) (respiratory symptoms: OR, 4.07 [95% CI, 1.88-8.80]; FEV(1) adjusted difference: -166 [95% CI, -263 to -70]) than in women with BMIs of 23 to 28 kg/m(2) (respiratory symptoms: OR, 1.10 [95% CI, 0.61-1.97], P(interaction): .04; FEV(1) adjusted difference, -54 [95% CI, -151 to 43], P(interaction) = .06).

CONCLUSIONS:

Menopause is associated with lower lung function and more respiratory symptoms, especially among lean women.

PMID:
18028993
[PubMed - indexed for MEDLINE]
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