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Domestication of animals is known to be associated with hereditary changes in the pituitary-adrenal system which regulates most important stages of ontogenesis. Cortisol is one of the basic indices of activity of this system. A segregation analysis of inheritance of cortisol content in blood of domestic silver fox population was undertaken. The results of the analysis point to an effect of a major gene controlling this quantitative trait, and indicate that breeding for domestic behaviour is accompanied by selection of individuals homozygous with respect to recessive genes controlling the cortisol level.
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