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Nat Neurosci. 2007 Dec;10(12):1538-43. Epub 2007 Nov 18.

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.

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  • 1University of British Columbia, The Biomedical Research Centre, 2222 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Abstract

Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.

PMID:
18026097
[PubMed - indexed for MEDLINE]
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