AIDS. 2007 Nov 30;21(18):2533-4.

Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience.

Waters LJ, Mandalia S, Gazzard B, Nelson M.

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Department of GU/HIV Medicine, St Stephen's Centre, Chelsea and Westminster Hospital, London, UK.

Abstract

Suspected hypersensitivity is the main reason for the early discontinuation of abacavir. After the observation that the risk of hypersensitivity correlated with ethnicity, the presence of the HLA allele B5701 was found to be the strongest retrospective predictor of hypersensitivity. Two prospective cohorts have since demonstrated a significant reduction in abacavir hypersensitivity rates with the use of prospective human leukocyte antigen screening. We describe our experience of prospective HLA-B5701 testing and the impact on rates of abacavir hypersensitivity.

PMID:: 18025891; [PubMed - indexed for MEDLINE]

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Chemical compound information

abacavir

MW: 286.33 g/mol

MF: C₁₄H₁₈N₆O

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Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience.

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