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Haematologica. 2007 Nov;92(11):e118-9.

Interferon alpha induces a good molecular response in a patient with chronic eosinophilic leukemia (CEL) carrying the JAK2V617F point mutation.

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  • 1Departament of Haematology and Bone Marrow Transplantation, Silesian Medical University, 40-027 Katowice, Dabrowski str. 25, Poland.


The JAK2 V617F point mutation is very rare in hypereosinophilic syndrome and/or chronic eosinophilic leukemia. Here we report on a patient with chronic eosinophilic leukemia and detectable JAK2 mutant clone, who achieved a good molecular response to interferon alpha-2a after 4 months of treatment. The molecular response correlated with only moderate haematological improvement.

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