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Trends Parasitol. 2008 Jan;24(1):29-34. Epub 2007 Nov 26.

Targeting the Plasmodium vivax Duffy-binding protein.

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  • 1Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India. <>


Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.

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