Trends Parasitol. 2008 Jan;24(1):29-34. Epub 2007 Nov 26.

Targeting the Plasmodium vivax Duffy-binding protein.

Source

Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India. cchitnis@icgeb.res.in <cchitnis@icgeb.res.in>

Abstract

Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.

PMID:: 18023618; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Blood - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Antibodies raised against receptor-binding domain of Plasmodium knowlesi Duffy binding protein inhibit erythrocyte invasion. [Mol Biochem Parasitol. 2002]
Antibodies raised against receptor-binding domain of Plasmodium knowlesi Duffy binding protein inhibit erythrocyte invasion.
Singh AP, Puri SK, Chitnis CE. Mol Biochem Parasitol. 2002 Apr 30; 121(1):21-31.
Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion. [Mol Microbiol. 2005]
Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion.
Hans D, Pattnaik P, Bhattacharyya A, Shakri AR, Yazdani SS, Sharma M, Choe H, Farzan M, Chitnis CE. Mol Microbiol. 2005 Mar; 55(5):1423-34.
Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC). [Mol Microbiol. 2005]
Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC).
Choe H, Moore MJ, Owens CM, Wright PL, Vasilieva N, Li W, Singh AP, Shakri R, Chitnis CE, Farzan M. Mol Microbiol. 2005 Mar; 55(5):1413-22.
Review [Molecular basis and structure-activity relationships of the Duffy blood group antigens: chemokine and Plasmodium vivax receptors]. [Transfus Clin Biol. 2000]
Review [Molecular basis and structure-activity relationships of the Duffy blood group antigens: chemokine and Plasmodium vivax receptors].
Tournamille C. Transfus Clin Biol. 2000 Oct; 7(5):497-509.
Review Red blood cell polymorphism and susceptibility to Plasmodium vivax. [Adv Parasitol. 2013]
Review Red blood cell polymorphism and susceptibility to Plasmodium vivax.
Zimmerman PA, Ferreira MU, Howes RE, Mercereau-Puijalon O. Adv Parasitol. 2013; 81:27-76.

See reviews... See all...

Cited by 12 PubMed Central articles

A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. [Blood. 2011]
A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax.
Russell B, Suwanarusk R, Borlon C, Costa FT, Chu CS, Rijken MJ, Sriprawat K, Warter L, Koh EG, Malleret B, et al. Blood. 2011 Sep 29; 118(13):e74-81. Epub 2011 Jul 18.
Plasmodium vivax: comparison of immunogenicity among proteins expressed in the cell-free systems of Escherichia coli and wheat germ by suspension array assays. [Malar J. 2011]
Plasmodium vivax: comparison of immunogenicity among proteins expressed in the cell-free systems of Escherichia coli and wheat germ by suspension array assays.
Rui E, Fernandez-Becerra C, Takeo S, Sanz S, Lacerda MV, Tsuboi T, del Portillo HA. Malar J. 2011 Jul 14; 10:192. Epub 2011 Jul 14.
Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans? [J Parasitol Res. 2011]
Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?
Bargieri DY, Soares IS, Costa FT, Braga CJ, Ferreira LC, Rodrigues MM. J Parasitol Res. 2011; 2011:965369. Epub 2011 Mar 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Targeting the Plasmodium vivax Duffy-binding protein.
Targeting the Plasmodium vivax Duffy-binding protein.
Trends Parasitol. 2008 Jan ;24(1):29-34. Epub 2007 Nov 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Targeting the Plasmodium vivax Duffy-binding protein.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 12 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information