Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. kjk1@cornell.edu
Understanding the biology of C. elegans relies on identification and analysis of essential genes, genes required for growth to a fertile adult. Approaches for identifying essential genes include several types of classical forward genetic screens, genome-wide RNA interference screens and systematic targeted gene knockout. Based on most estimates made from screening results thus far, from 15-30% of C. elegans genes appear to be essential. Genetic redundancy masks some essential functions and pleiotropy of many essential genes poses a challenge for a full understanding of their functions. Temperature sensitive mutations are valuable tools for studies of essential genes, but our ability to analyze essential genes would benefit from development of new tools for conditional inactivation or activation of specific genes.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on