Critical evaluation of 1H NMR metabonomics of seru...[Clin Chem Lab Med. 2008]

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1: Clin Chem Lab Med. 2008;46(1):27-42. Links

Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics.

Ala-Korpela M.

Laboratory of Computational Engineering, Systems Biology and Bioinformation Technology, Helsinki University of Technology, Espoo, Finland. mika.ala-korpela@hut.fi

This review focuses on (i) the current status of 1H NMR spectroscopy to quantify lipoprotein subclasses directly from serum or plasma, and (ii) the applications of 1H NMR metabonomics of serum in biomedicine. Related to both themes, experimental and data analysis methodologies are discussed together with the biochemical rationales. Particular emphasis is placed on the concepts of risk assessment and diagnostics in relation to the potential clinical role of 1H NMR metabonomics; recent applications in the area of coronary heart disease and diabetes are addressed in more detail.

PMID: 18020967 [PubMed - indexed for MEDLINE]

A novel Bayesian approach to quantify clinical variables and to determine their spectroscopic counterparts in 1H NMR metabonomic data.
BMC Bioinformatics. 2007 May 3; 8 Suppl 2:S8. Epub 2007 May 3.

[BMC Bioinformatics. 2007]
ReviewPotential role of body fluid 1H NMR metabonomics as a prognostic and diagnostic tool.
Expert Rev Mol Diagn. 2007 Nov; 7(6):761-73.

[Expert Rev Mol Diagn. 2007]
Diagnosing diabetic nephropathy by 1H NMR metabonomics of serum.
MAGMA. 2006 Dec; 19(6):281-96. Epub 2006 Dec 15.

[MAGMA. 2006]
1H NMR metabonomics of plasma lipoprotein subclasses: elucidation of metabolic clustering by self-organising maps.
NMR Biomed. 2007 Nov; 20(7):658-72.

[NMR Biomed. 2007]
ReviewMetabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis.
Curr Opin Chem Biol. 2003 Oct; 7(5):648-54.

[Curr Opin Chem Biol. 2003]
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Cited by 1 PubMed Central article

1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death.
Mäkinen VP, Soininen P, Forsblom C, Parkkonen M, Ingman P, Kaski K, Groop PH, FinnDiane Study Group, Ala-Korpela M. Mol Syst Biol. 2008; 4:167. Epub 2008 Feb 12.

[Mol Syst Biol. 2008]

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