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Org Biomol Chem. 2007 Aug 21;5(16):2541-54.

Nicotinamide adenine dinucleotide: beyond a redox coenzyme.

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  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. hl379@cornell.edu

Abstract

ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)-transferases (ARTs), NAD(+)-dependent deacetylases (sirtuins), tRNA 2'-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

PMID:
18019526
[PubMed - indexed for MEDLINE]
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